I like to make it clear that i think the soul is not a little man in the brain but is similar to the physical body. Nonetheless materialists argue that if there is an observer in the body that observer would require other observers and so on. The major problem with this is if the soul is immortal their wouldn't be no need for an infinite amount of observers [souls]. In the arena of neuroscience the common held view is that consciousness and the mind is an emergent property of the brain. Then their are some scientists who disagree and postulate that consciousness is an illusion created by the brain.
I think in order for us to solve the mind body problem we much embrace substance dualism. Obviously substance dualism has been tied to religion however their are some dualists such as me that don't go to church or read an bible. Also aren't associated with any other religions.